abstract：BACKGROUND:Rapid diagnostic tests (RDTs) for malaria provide a practical alternative to light microscopy for malaria diagnosis in resource-limited settings. Three-band RDTs incorporating two parasite antigens may have enhanced diagnostic specificity, relative to two-band RDTs with a single parasite antigen (typically h...

journal_title：Malaria journal

authors： Hawkes M,Conroy AL,Opoka RO,Namasopo S,Liles WC,John CC,Kain KC

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Pyrethroid-resistant mosquitoes are an increasing threat to malaria vector control. The Global Plan for Insecticide Resistance Management (GPIRM) recommends rotation of non-pyrethroid insecticides for indoor residual spraying (IRS). The options from other classes are limited. The carbamate bendiocarb and the...

journal_title：Malaria journal

authors： Oxborough RM,Kitau J,Jones R,Feston E,Matowo J,Mosha FW,Rowland MW

更新日期：2014-01-29 00:00:00

abstract：BACKGROUND:Knowledge of the ecology and behaviour of a target species is a prerequisite for the successful development of any vector control strategy. Before the implementation of any strategy it is essential to have comprehensive information on the bionomics of species in the targeted area. The aims of this study were...

journal_title：Malaria journal

authors： Munhenga G,Brooke BD,Spillings B,Essop L,Hunt RH,Midzi S,Govender D,Braack L,Koekemoer LL

更新日期：2014-01-24 00:00:00

abstract：BACKGROUND:The decline in efficacy of artesunate (AS) and mefloquine (MQ) is now the major concern in areas along the Thai-Cambodian and Thai-Myanmar borders. METHODS:The correlation between polymorphisms of pfatp6, pfcrt, pfmdr1 and pfmrp1 genes and in vitro sensitivity of Plasmodium falciparum isolates to the artemi...

journal_title：Malaria journal

authors： Phompradit P,Muhamad P,Wisedpanichkij R,Chaijaroenkul W,Na-Bangchang K

更新日期：2014-01-15 00:00:00

abstract：BACKGROUND:The WHO has reported that RDT and microscopy-confirmed malaria cases have declined in recent years. However, it is still unclear if this reflects a real decrease in incidence in Bangladesh, as particularly the hilly and forested areas of the Chittagong Hill Tract (CHT) Districts report more than 80% of all c...

journal_title：Malaria journal

authors： Starzengruber P,Fuehrer HP,Ley B,Thriemer K,Swoboda P,Habler VE,Jung M,Graninger W,Khan WA,Haque R,Noedl H

更新日期：2014-01-09 00:00:00

abstract：BACKGROUND:In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies had become ineffective in many parts of the world. As a result, the Democratic Republic of Congo (DRC) withdrew chlo...

journal_title：Malaria journal

authors： Mvumbi DM,Boreux R,Sacheli R,Lelo M,Lengu B,Nani-Tuma S,Melin P,Ntumba K,Lunganza K,DeMol P,Hayette MP

更新日期：2013-12-20 00:00:00

abstract：BACKGROUND:The emergence of parasite drug resistance, especially Plasmodium falciparum, persists as a major obstacle for malaria control and elimination. To develop effective public health containment strategies, a clear understanding of factors that govern the emergence and spread of resistant parasites in the field i...

journal_title：Malaria journal

authors： Mharakurwa S,Sialumano M,Liu K,Scott A,Thuma P

更新日期：2013-12-19 00:00:00

abstract：BACKGROUND:Plasmodium knowlesi is the fifth Plasmodium species that can infect humans. The Plasmodium merozoite surface protein-1(42) (MSP-1(42)) is a potential candidate for malaria vaccine. However, limited studies have focused on P. knowlesi MSP-1(42). METHODS:A ~42 kDa recombinant P. knowlesi MSP-1(42) (pkMSP-1(42...

journal_title：Malaria journal

authors： Cheong FW,Fong MY,Lau YL,Mahmud R

更新日期：2013-12-19 00:00:00

abstract：BACKGROUND:Transmission of Plasmodium vivax malaria is dependent on vector availability, biting rates and parasite development. In turn, each of these is influenced by climatic conditions. Correlations have previously been detected between seasonal rainfall, temperature and malaria incidence patterns in various setting...

journal_title：Malaria journal

authors： Wardrop NA,Barnett AG,Atkinson JA,Clements AC

更新日期：2013-12-18 00:00:00

abstract：BACKGROUND:The sulphadoxine/pyrimethamine (SDX/PYR) combination had been chosen to treat uncomplicated falciparum malaria in Malaysia for more than 30 years. Non-silent mutations in dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes are responsible for the resistance to pyrimethamine and sulphadox...

journal_title：Malaria journal

authors： Lau TY,Sylvi M,William T

更新日期：2013-12-10 00:00:00

abstract：BACKGROUND:For future eradication strategies of malaria it is important to control the transmission of gametocytes from humans to the anopheline vector which causes the spread of the disease. Sensitive, non-invasive methods to detect gametocytes under field conditions can play a role in monitoring transmission potentia...

journal_title：Malaria journal

authors： Kast K,Berens-Riha N,Zeynudin A,Abduselam N,Eshetu T,Löscher T,Wieser A,Shock J,Pritsch M

更新日期：2013-12-04 00:00:00

abstract：BACKGROUND:This paper reports on the availability of diagnostic tools and recommended anti-malarials in the 12-month period immediately following the implementation of a new national malaria treatment protocol (NMTP) in Papua New Guinea (PNG). Health worker adherence to the new NMTP is also examined and comparisons mad...

journal_title：Malaria journal

authors： Pulford J,Kurumop SF,Ura Y,Siba PM,Mueller I,Hetzel MW

更新日期：2013-11-27 00:00:00

abstract：BACKGROUND:Recent whole cell in vitro screening campaigns identified thousands of compounds that are active against asexual blood stages of Plasmodium falciparum at submicromolar concentrations. These hits have been made available to the public, providing many novel chemical starting points for anti-malarial drug disco...

journal_title：Malaria journal

authors： Le Manach C,Scheurer C,Sax S,Schleiferböck S,Cabrera DG,Younis Y,Paquet T,Street L,Smith P,Ding XC,Waterson D,Witty MJ,Leroy D,Chibale K,Wittlin S

更新日期：2013-11-16 00:00:00

abstract：BACKGROUND:Each year, thousands of cases of uncomplicated malaria are imported into Europe by travellers. Atovaquone-proguanil (AP) has been one of the first-line regimens used in France for uncomplicated malaria for almost ten years. While AP's efficacy and tolerance were evaluated in several trials, its use in "real ...

journal_title：Malaria journal

authors： Cordel H,Cailhol J,Matheron S,Bloch M,Godineau N,Consigny PH,Gros H,Campa P,Bourée P,Fain O,Ralaimazava P,Bouchaud O

更新日期：2013-11-07 00:00:00

abstract：BACKGROUND:Experimental vaccines targeting Plasmodium falciparum have had some success in recent years. These vaccines use attenuated parasites, recombinant sporozoite proteins, or DNA and virus combinations to induce cell-mediated immune responses and/or antibodies targeting sporozoite surface proteins. To capitalize ...

journal_title：Malaria journal

authors： Zou X,House BL,Zyzak MD,Richie TL,Gerbasi VR

更新日期：2013-11-05 00:00:00

abstract：BACKGROUND:Recent progress in malaria control has caused renewed interest in mass drug administration (MDA) as a potential elimination strategy but the evidence base is limited. China has extensive experience with MDA, but it is not well documented. METHODS:An ecological study was conducted to describe the use of MDA ...

journal_title：Malaria journal

authors： Hsiang MS,Hwang J,Tao AR,Liu Y,Bennett A,Shanks GD,Cao J,Kachur SP,Feachem RG,Gosling RD,Gao Q

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:With the introduction of artemisinin-based combination therapy (ACT) in 2005, monitoring of anti-malarial drug efficacy, which includes the use of molecular tools to detect known genetic markers of parasite resistance, is important for first-hand information on the changes in parasite susceptibility to drugs...

journal_title：Malaria journal

authors： Duah NO,Matrevi SA,de Souza DK,Binnah DD,Tamakloe MM,Opoku VS,Onwona CO,Narh CA,Quashie NB,Abuaku B,Duplessis C,Kronmann KC,Koram KA

更新日期：2013-10-30 00:00:00

abstract：BACKGROUND:The merozoite surface protein 1 (msp1) is one of the most studied vaccine candidate genes in mammalian Plasmodium spp. to have been used for investigations of epidemiology, population structures, and immunity to infections. However methodological difficulties have impeded the use of nuclear markers such as m...

journal_title：Malaria journal

authors： Hellgren O,Kutzer M,Bensch S,Valkiūnas G,Palinauskas V

更新日期：2013-10-30 00:00:00

abstract：BACKGROUND:Malaria is responsible for up to a 600,000 deaths per year; conveying an urgent need for the development of a malaria vaccine. Studies with whole sporozoite vaccines in mice and non-human primates have shown that sporozoite-induced CD8+ T cells targeting liver stage antigens can mediate sterile protection. T...

journal_title：Malaria journal

authors： Schwenk R,Banania G,Epstein J,Kim Y,Peters B,Belmonte M,Ganeshan H,Huang J,Reyes S,Stryhn A,Ockenhouse CF,Buus S,Richie TL,Sedegah M

更新日期：2013-10-29 00:00:00

abstract：BACKGROUND:The close relationship between vector-borne diseases and their environment is well documented, especially for diseases with water-dependent vectors such as avian malaria. Mosquitoes are the primary vectors of avian malaria and also the definitive hosts in the disease life cycle. Factors pertinent to mosquito...

journal_title：Malaria journal

authors： Okanga S,Cumming GS,Hockey PA

更新日期：2013-10-25 00:00:00

abstract：:Malaria is a public health problem in French Guiana. Plasmodium vivax is the most frequent parasite. The objective of this analysis was to estimate the proportion of relapses in the burden of vivax malaria using the statistical rule stating that any case of vivax malaria occurring less than 90 days following a first e...

journal_title：Malaria journal

authors： Nacher M,Stefani A,Basurko C,Lemonnier D,Djossou F,Demar M,Elenga N,Brousse P,Ville M,Carme B

更新日期：2013-10-24 00:00:00

abstract：BACKGROUND:Malaria is a potentially lethal illness for which preventive measures are not optimally used among all travellers. Travellers visiting friends and relatives in their country of origin (VFRs) are known to use chemoprophylaxis less consistently compared to tourist travellers. In this study, factors explaining ...

journal_title：Malaria journal

authors： Wieten RW,Harting J,Biemond PM,Grobusch MP,van Vugt M

更新日期：2013-10-10 00:00:00

abstract：BACKGROUND:Prompt and effective malaria diagnosis not only alleviates individual suffering, but also decreases malaria transmission at the community level. The commonly used diagnostic methods, microscopy and rapid diagnostic tests, are usually insensitive at very low-density parasitaemia. Molecular techniques, on the ...

journal_title：Malaria journal

authors： Golassa L,Enweji N,Erko B,Aseffa A,Swedberg G

更新日期：2013-10-03 00:00:00

abstract：BACKGROUND:Drug combination therapy is the frontline of malaria treatment. There is an ever-accelerating need for new, efficacious combination therapies active against drug resistant malaria. Proven drugs already in the treatment pipeline, such as the quinolines, are important components of current combination therapy ...

journal_title：Malaria journal

authors： Gorka AP,Jacobs LM,Roepe PD

更新日期：2013-09-18 00:00:00

abstract：BACKGROUND:The screening of lead compounds against in vitro parasite cultures is an essential step in the development of novel anti-malarial drugs, but currently relies on laboratory parasite lines established in vitro during the last century. This study sought to establish in continuous culture a series of recent Plas...

journal_title：Malaria journal

authors： van Schalkwyk DA,Burrow R,Henriques G,Gadalla NB,Beshir KB,Hasford C,Wright SG,Ding XC,Chiodini PL,Sutherland CJ

更新日期：2013-09-13 00:00:00

abstract：:Plasmodium falciparum infections present novel challenges for vaccine development, including parasite replication dynamics not previously encountered for viral pathogens, and enormous diversity in target antigens. These challenges are illustrated by using a mathematical model to describe the association between the pr...

journal_title：Malaria journal

authors： White MT,Smith DL

更新日期：2013-08-08 00:00:00

abstract：BACKGROUND:Although chemoprophylaxis remains an important strategy for preventing malaria in travellers, its effectiveness may be compromised by lack of adherence. Inappropriate use of chemoprophylaxis is likely to increase the risk of acquiring malaria, but may probably also worsen the severity of imported cases. The ...

journal_title：Malaria journal

authors： Vliegenthart-Jongbloed K,de Mendonça Melo M,van Wolfswinkel ME,Koelewijn R,van Hellemond JJ,van Genderen PJ

更新日期：2013-07-31 00:00:00

abstract：BACKGROUND:Inter-individual variability in plasma concentration-time profiles might contribute to differences in anti-malarial treatment response. This study investigated the pharmacokinetics of three different forms of artemisinin combination therapy (ACT) in Tanzania and Cambodia to quantify and identify potential so...

journal_title：Malaria journal

authors： Staehli Hodel EM,Guidi M,Zanolari B,Mercier T,Duong S,Kabanywanyi AM,Ariey F,Buclin T,Beck HP,Decosterd LA,Olliaro P,Genton B,Csajka C

更新日期：2013-07-10 00:00:00

abstract：BACKGROUND:Plasmodium infections trigger complex immune reactions from their hosts against several life stages of the parasite, including gametocytes. These immune responses are highly variable, depending on age, genetics, and exposure history of the host as well as species and strain of parasite. Although the effects ...

journal_title：Malaria journal

authors： McQueen PG,Williamson KC,McKenzie FE

更新日期：2013-06-15 00:00:00

abstract：BACKGROUND:Sulphadoxine-pyrimethamine (SP) has been in use for the treatment of uncomplicated falciparum malaria in Malaysia since the 1970s and is still widely employed in spite of widespread clinical resistance. Resistance to SP is known to be mediated by mutations in the pfdhfr and pfdhps genes. The aim of the prese...

journal_title：Malaria journal

authors： Abdullah NR,Norahmad NA,Jelip J,Sulaiman LH,Mohd Sidek H,Ismail Z,Noedl H

更新日期：2013-06-12 00:00:00

abstract：BACKGROUND:Most rapid diagnostic tests (RDTs) currently used for malaria diagnosis cannot distinguish the various Plasmodium infections. The development of a Plasmodium vivax specific RDTs with high sensitivity to sufficiently differentiate the two most common Plasmodium infections would be very crucial for disease tre...

journal_title：Malaria journal

authors： Dzakah EE,Kang K,Ni C,Wang H,Wu P,Tang S,Wang J,Wang J,Wang X

更新日期：2013-06-12 00:00:00

abstract：BACKGROUND:Plasmodium falciparum circumsporozoite protein (CSP) is a leading malaria vaccine candidate antigen, known to elicit protective antibody responses in humans (RTS,S vaccine). Recently, a DNA prime / adenovirus (Ad) vector boost vaccine encoding CSP and a second P. falciparum antigen, apical membrane antigen-1...

journal_title：Malaria journal

authors： Sedegah M,Kim Y,Ganeshan H,Huang J,Belmonte M,Abot E,Banania JG,Farooq F,McGrath S,Peters B,Sette A,Soisson L,Diggs C,Doolan DL,Tamminga C,Villasante E,Hollingdale MR,Richie TL

更新日期：2013-06-05 00:00:00

abstract：BACKGROUND:The malaria rapid diagnostic tests (RDTs) are now widely used in the world. Compared to Plasmodium falciparum, a poor sensitivity of RDTs was reported against Plasmodium vivax based on the adopted antibody against pan-Plasmodium antigen lactate dehydrogenase (pLDH) or aldolase. Levels of pLDH were measured f...

journal_title：Malaria journal

authors： Jang JW,Cho CH,Han ET,An SS,Lim CS

更新日期：2013-06-03 00:00:00

abstract：BACKGROUND:A successful malaria control programme began in 2004 on Bioko Island, Equatorial Guinea. From 2007, the same multiple malaria interventions, though reduced in scope for funding reasons, were introduced to the four mainland provinces of Equatorial Guinea (the continental region) aiming to recreate Bioko's suc...

journal_title：Malaria journal

authors： Rehman AM,Mann AG,Schwabe C,Reddy MR,Roncon Gomes I,Slotman MA,Yellott L,Matias A,Caccone A,Nseng Nchama G,Kleinschmidt I

更新日期：2013-05-07 00:00:00

abstract：:April 25 marks World Malaria Day, an opportunity for those who work to defeat the illness, to review progress and renew commitments. After a decade of steady success, this year's commemoration of the date is also an opportunity to reconsider current approaches and assess the state of the science needed to keep pace in...

journal_title：Malaria journal

authors： Slutsker L,Kachur SP

更新日期：2013-04-24 00:00:00

abstract：BACKGROUND:Malaria rapid diagnostic tests (RDT) are used for diagnostic purpose in malaria-endemic areas where reliable microscopy is not available. Persistence of the antigenaemia causes over-diagnosis and may limit the usefulness of the RDT in monitoring treatment. In this study, the usefulness of histidine-rich prot...

journal_title：Malaria journal

authors： Nyunt MH,Kyaw MP,Win KK,Myint KM,Nyunt KM

更新日期：2013-04-11 00:00:00

abstract：BACKGROUND:In Plasmodium, the high level of genetic diversity and the interactions established by co-infecting parasite populations within the same host may be a source of selection on pathogen virulence and drug resistance. As different patterns have already been described in humans and mosquitoes, parasite diversity ...

journal_title：Malaria journal

authors： Mendes C,Salgueiro P,Gonzalez V,Berzosa P,Benito A,do Rosário VE,de Sousa B,Cano J,Arez AP

更新日期：2013-03-27 00:00:00

abstract：BACKGROUND:A high-resolution surveillance-response system has been developed within a geographic information system (GIS) to support malaria elimination in the Pacific. This paper examines the application of a GIS-based spatial decision support system (SDSS) to automatically locate and map the distribution of confirmed...

journal_title：Malaria journal

authors： Kelly GC,Hale E,Donald W,Batarii W,Bugoro H,Nausien J,Smale J,Palmer K,Bobogare A,Taleo G,Vallely A,Tanner M,Vestergaard LS,Clements AC

更新日期：2013-03-21 00:00:00

abstract：BACKGROUND:T1BT* is a peptide construct containing the T1 and B epitopes located in the 5' minor repeat and the 3' major repeat of the central repeat region of the Plasmodium falciparum circumsporozoite protein (CSP), respectively, and the universal T* epitope located in the C-terminus of the same protein. This peptide...

journal_title：Malaria journal

authors： Topchiy E,Armstrong GS,Boswell KI,Buchner GS,Kubelka J,Lehmann TE

更新日期：2013-03-18 00:00:00

abstract：BACKGROUND:Relatively few programmes have attempted to actively engage the private sector in national malaria control efforts. This paper evaluates the health impact of a large-scale distribution of insecticide-treated nets (ITNs) conducted in partnership with a Zambian agribusiness, and its cost-effectiveness from the...

journal_title：Malaria journal

authors： Sedlmayr R,Fink G,Miller JM,Earle D,Steketee RW

更新日期：2013-03-18 00:00:00